Strontium ranelate reduces the risk of vertebral and nonvertebral fractures in women eighty years of age and older
Identifieur interne : 009C04 ( Main/Exploration ); précédent : 009C03; suivant : 009C05Strontium ranelate reduces the risk of vertebral and nonvertebral fractures in women eighty years of age and older
Auteurs : Ego Seeman [Australie] ; Bruno Vellas [France] ; Claude Benhamou [France] ; Jean Pierre Aquino [France] ; Jutta Semler [Allemagne] ; Jean Marc Kaufman [Belgique] ; Krzysztof Hoszowski [Pologne] ; Alfredo Roces Varela [Espagne] ; Carmelo Fiore [Italie] ; Kim Brixen [Danemark] ; Jean Yves Reginster [Belgique] ; Steven Boonen [Belgique]Source :
- Journal of bone and mineral research : (Print) [ 0884-0431 ] ; 2006.
Descripteurs français
- Pascal (Inist)
English descriptors
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Abstract
Strontium ranelate produces an early and sustained reduction of both vertebral and nonvertebral fractures in patients ≥80 years of age. Introduction: About 25-30% of the population burden of all fragility fractures in the community arise from women ≥80 years of age, because this population is at high risk for all types of fracture, particularly nonvertebral fractures. Despite this, evidence that therapies reduce the risk of both vertebral and nonvertebral fractures in this group is lacking. The aim of this study was to determine whether strontium ranelate, an agent that reduces the risk of vertebral and nonvertebral fractures in postmenopausal women >50 years of age, also reduces fractures in the elderly. Materials and Methods: An analysis based on preplanned pooling of data from two international, phase III, randomized, placebo-controlled, double-blind studies (the Spinal Osteoporosis Therapeutic Intervention [SOTI] and TReatment Of Peripheral OSteoporosis [TROPOS]) included 1488 women between 80 and 100 years of age followed for 3 years. Yearly spinal X-rays were performed in 895 patients. Only radiographically confirmed nonvertebral fractures were included. Results: Baseline characteristics did not differ in placebo and treatment arms. In the intent-to-treat analysis, the risk of vertebral, nonvertebral, and clinical (symptomatic vertebral and nonvertebral) fractures was reduced within 1 year by 59% (p = 0.002), 41% (p = 0.027), and 37% (p = 0.012), respectively. At the end of 3 years, vertebral, nonvertebral, and clinical fracture risks were reduced by 32% (p = 0.013), 31% (p = 0.011), and 22% (p = 0.040), respectively. The medication was well tolerated, and the safety profile was similar to that in younger patients. Conclusions: Treatment with strontium ranelate safely reduces the risk of vertebral and nonvertebral fractures in women with osteoporosis ≥80 years of age. Even in the oldest old, it is not too late to reduce fracture risk.
Affiliations:
- Allemagne, Australie, Belgique, Danemark, Espagne, France, Italie, Pologne
- Berlin, Centre-Val de Loire, Midi-Pyrénées, Occitanie (région administrative), Province de Liège, Région Centre, Région wallonne, Victoria (État), Île-de-France
- Berlin, Liège, Melbourne, Orléans, Toulouse, Versailles
- Université de Liège, Université de Melbourne
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Gent Department of Internal Medicine</s1><s2>Gent</s2><s3>BEL</s3><sZ>6 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>U.Z. Gent Department of Internal Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Hoszowski, Krzysztof" sort="Hoszowski, Krzysztof" uniqKey="Hoszowski K" first="Krzysztof" last="Hoszowski">Krzysztof Hoszowski</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Centrum Medyczcne</s1><s2>Warsaw</s2><s3>POL</s3><sZ>7 aut.</sZ></inist:fA14><country>Pologne</country><wicri:noRegion>Centrum Medyczcne</wicri:noRegion></affiliation></author><author><name sortKey="Varela, Alfredo Roces" sort="Varela, Alfredo Roces" uniqKey="Varela A" first="Alfredo Roces" last="Varela">Alfredo Roces Varela</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Rheumatology, Hospital Universitario N. S. de Candelaria</s1><s2>Tenerife, Canary Islands</s2><s3>ESP</s3><sZ>8 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Tenerife, Canary Islands</wicri:noRegion></affiliation></author><author><name sortKey="Fiore, Carmelo" sort="Fiore, Carmelo" uniqKey="Fiore C" first="Carmelo" last="Fiore">Carmelo Fiore</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Clinica Medica Ove, University of Catania</s1><s2>Catania</s2><s3>ITA</s3><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Catania</wicri:noRegion></affiliation></author><author><name sortKey="Brixen, Kim" sort="Brixen, Kim" uniqKey="Brixen K" first="Kim" last="Brixen">Kim Brixen</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Odense University Hospital</s1><s2>Odense</s2><s3>DNK</s3><sZ>10 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Odense University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Reginster, Jean Yves" sort="Reginster, Jean Yves" uniqKey="Reginster J" first="Jean Yves" last="Reginster">Jean Yves Reginster</name><affiliation wicri:level="4"><inist:fA14 i1="11"><s1>University of Liège</s1><s2>Liège</s2><s3>BEL</s3><sZ>11 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Liège</region></placeName><orgName type="university">Université de Liège</orgName></affiliation></author><author><name sortKey="Boonen, Steven" sort="Boonen, Steven" uniqKey="Boonen S" first="Steven" last="Boonen">Steven Boonen</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Leuven University Center for Metabolic Bone Diseases and Division of Geriatric Medicine</s1><s2>Leuven</s2><s3>BEL</s3><sZ>12 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Leuven University Center for Metabolic Bone Diseases and Division of Geriatric Medicine</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">06-0348072</idno><date when="2006">2006</date><idno type="stanalyst">PASCAL 06-0348072 INIST</idno><idno type="RBID">Pascal:06-0348072</idno><idno type="wicri:Area/PascalFrancis/Corpus">004293</idno><idno type="wicri:Area/PascalFrancis/Curation">001E02</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">003C65</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">003C65</idno><idno type="wicri:doubleKey">0884-0431:2006:Seeman E:strontium:ranelate:reduces</idno><idno type="wicri:Area/Main/Merge">00A687</idno><idno type="wicri:Area/Main/Curation">009C04</idno><idno type="wicri:Area/Main/Exploration">009C04</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Strontium ranelate reduces the risk of vertebral and nonvertebral fractures in women eighty years of age and older</title><author><name sortKey="Seeman, Ego" sort="Seeman, Ego" uniqKey="Seeman E" first="Ego" last="Seeman">Ego Seeman</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Austin Hospital, University of Melbourne</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>1 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Vellas, Bruno" sort="Vellas, Bruno" uniqKey="Vellas B" first="Bruno" last="Vellas">Bruno Vellas</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CHU Purpan</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>2 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Benhamou, Claude" sort="Benhamou, Claude" uniqKey="Benhamou C" first="Claude" last="Benhamou">Claude Benhamou</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Hopital de la Madeleine</s1><s2>Orleans</s2><s3>FRA</s3><sZ>3 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Orléans</settlement></placeName></affiliation></author><author><name sortKey="Aquino, Jean Pierre" sort="Aquino, Jean Pierre" uniqKey="Aquino J" first="Jean Pierre" last="Aquino">Jean Pierre Aquino</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Clinique Médicale de la Porte Verte</s1><s2>Versailles</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Versailles</settlement></placeName></affiliation></author><author><name sortKey="Semler, Jutta" sort="Semler, Jutta" uniqKey="Semler J" first="Jutta" last="Semler">Jutta Semler</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Immanuel Krankenhaus Rheumaklinik</s1><s2>Berlin</s2><s3>DEU</s3><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Kaufman, Jean Marc" sort="Kaufman, Jean Marc" uniqKey="Kaufman J" first="Jean Marc" last="Kaufman">Jean Marc Kaufman</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>U.Z. Gent Department of Internal Medicine</s1><s2>Gent</s2><s3>BEL</s3><sZ>6 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>U.Z. Gent Department of Internal Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Hoszowski, Krzysztof" sort="Hoszowski, Krzysztof" uniqKey="Hoszowski K" first="Krzysztof" last="Hoszowski">Krzysztof Hoszowski</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Centrum Medyczcne</s1><s2>Warsaw</s2><s3>POL</s3><sZ>7 aut.</sZ></inist:fA14><country>Pologne</country><wicri:noRegion>Centrum Medyczcne</wicri:noRegion></affiliation></author><author><name sortKey="Varela, Alfredo Roces" sort="Varela, Alfredo Roces" uniqKey="Varela A" first="Alfredo Roces" last="Varela">Alfredo Roces Varela</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Rheumatology, Hospital Universitario N. S. de Candelaria</s1><s2>Tenerife, Canary Islands</s2><s3>ESP</s3><sZ>8 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Tenerife, Canary Islands</wicri:noRegion></affiliation></author><author><name sortKey="Fiore, Carmelo" sort="Fiore, Carmelo" uniqKey="Fiore C" first="Carmelo" last="Fiore">Carmelo Fiore</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Clinica Medica Ove, University of Catania</s1><s2>Catania</s2><s3>ITA</s3><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Catania</wicri:noRegion></affiliation></author><author><name sortKey="Brixen, Kim" sort="Brixen, Kim" uniqKey="Brixen K" first="Kim" last="Brixen">Kim Brixen</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Odense University Hospital</s1><s2>Odense</s2><s3>DNK</s3><sZ>10 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Odense University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Reginster, Jean Yves" sort="Reginster, Jean Yves" uniqKey="Reginster J" first="Jean Yves" last="Reginster">Jean Yves Reginster</name><affiliation wicri:level="4"><inist:fA14 i1="11"><s1>University of Liège</s1><s2>Liège</s2><s3>BEL</s3><sZ>11 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Liège</region></placeName><orgName type="university">Université de Liège</orgName></affiliation></author><author><name sortKey="Boonen, Steven" sort="Boonen, Steven" uniqKey="Boonen S" first="Steven" last="Boonen">Steven Boonen</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Leuven University Center for Metabolic Bone Diseases and Division of Geriatric Medicine</s1><s2>Leuven</s2><s3>BEL</s3><sZ>12 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Leuven University Center for Metabolic Bone Diseases and Division of Geriatric Medicine</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Journal of bone and mineral research : (Print)</title><title level="j" type="abbreviated">J. bone miner. res. : (Print)</title><idno type="ISSN">0884-0431</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of bone and mineral research : (Print)</title><title level="j" type="abbreviated">J. bone miner. res. : (Print)</title><idno type="ISSN">0884-0431</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age</term><term>Female</term><term>Fracture</term><term>Mammalia</term><term>Osteoarticular system</term><term>Senescence</term><term>Strontium</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Strontium</term><term>Fracture</term><term>Femelle</term><term>Age</term><term>Sénescence</term><term>Mammalia</term><term>Système ostéoarticulaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Strontium ranelate produces an early and sustained reduction of both vertebral and nonvertebral fractures in patients ≥80 years of age. Introduction: About 25-30% of the population burden of all fragility fractures in the community arise from women ≥80 years of age, because this population is at high risk for all types of fracture, particularly nonvertebral fractures. Despite this, evidence that therapies reduce the risk of both vertebral and nonvertebral fractures in this group is lacking. The aim of this study was to determine whether strontium ranelate, an agent that reduces the risk of vertebral and nonvertebral fractures in postmenopausal women >50 years of age, also reduces fractures in the elderly. Materials and Methods: An analysis based on preplanned pooling of data from two international, phase III, randomized, placebo-controlled, double-blind studies (the Spinal Osteoporosis Therapeutic Intervention [SOTI] and TReatment Of Peripheral OSteoporosis [TROPOS]) included 1488 women between 80 and 100 years of age followed for 3 years. Yearly spinal X-rays were performed in 895 patients. Only radiographically confirmed nonvertebral fractures were included. Results: Baseline characteristics did not differ in placebo and treatment arms. In the intent-to-treat analysis, the risk of vertebral, nonvertebral, and clinical (symptomatic vertebral and nonvertebral) fractures was reduced within 1 year by 59% (p = 0.002), 41% (p = 0.027), and 37% (p = 0.012), respectively. At the end of 3 years, vertebral, nonvertebral, and clinical fracture risks were reduced by 32% (p = 0.013), 31% (p = 0.011), and 22% (p = 0.040), respectively. The medication was well tolerated, and the safety profile was similar to that in younger patients. Conclusions: Treatment with strontium ranelate safely reduces the risk of vertebral and nonvertebral fractures in women with osteoporosis ≥80 years of age. Even in the oldest old, it is not too late to reduce fracture risk.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Danemark</li><li>Espagne</li><li>France</li><li>Italie</li><li>Pologne</li></country><region><li>Berlin</li><li>Centre-Val de Loire</li><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li><li>Province de Liège</li><li>Région Centre</li><li>Région wallonne</li><li>Victoria (État)</li><li>Île-de-France</li></region><settlement><li>Berlin</li><li>Liège</li><li>Melbourne</li><li>Orléans</li><li>Toulouse</li><li>Versailles</li></settlement><orgName><li>Université de Liège</li><li>Université de Melbourne</li></orgName></list><tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Seeman, Ego" sort="Seeman, Ego" uniqKey="Seeman E" first="Ego" last="Seeman">Ego Seeman</name></region></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Vellas, Bruno" sort="Vellas, Bruno" uniqKey="Vellas B" first="Bruno" last="Vellas">Bruno Vellas</name></region><name sortKey="Aquino, Jean Pierre" sort="Aquino, Jean Pierre" uniqKey="Aquino J" first="Jean Pierre" last="Aquino">Jean Pierre Aquino</name><name sortKey="Benhamou, Claude" sort="Benhamou, Claude" uniqKey="Benhamou C" first="Claude" last="Benhamou">Claude Benhamou</name></country><country name="Allemagne"><region name="Berlin"><name sortKey="Semler, Jutta" sort="Semler, Jutta" uniqKey="Semler J" first="Jutta" last="Semler">Jutta Semler</name></region></country><country name="Belgique"><noRegion><name sortKey="Kaufman, Jean Marc" sort="Kaufman, Jean Marc" uniqKey="Kaufman J" first="Jean Marc" last="Kaufman">Jean Marc Kaufman</name></noRegion><name sortKey="Boonen, Steven" sort="Boonen, Steven" uniqKey="Boonen S" first="Steven" last="Boonen">Steven Boonen</name><name sortKey="Reginster, Jean Yves" sort="Reginster, Jean Yves" uniqKey="Reginster J" first="Jean Yves" last="Reginster">Jean Yves Reginster</name></country><country name="Pologne"><noRegion><name sortKey="Hoszowski, Krzysztof" sort="Hoszowski, Krzysztof" uniqKey="Hoszowski K" first="Krzysztof" last="Hoszowski">Krzysztof Hoszowski</name></noRegion></country><country name="Espagne"><noRegion><name sortKey="Varela, Alfredo Roces" sort="Varela, Alfredo Roces" uniqKey="Varela A" first="Alfredo Roces" last="Varela">Alfredo Roces Varela</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Fiore, Carmelo" sort="Fiore, Carmelo" uniqKey="Fiore C" first="Carmelo" last="Fiore">Carmelo Fiore</name></noRegion></country><country name="Danemark"><noRegion><name sortKey="Brixen, Kim" sort="Brixen, Kim" uniqKey="Brixen K" first="Kim" last="Brixen">Kim Brixen</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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